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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name H-Ras siRNA
ncRNA Category siRNA
Disease name diabetic retinopathy (DR)
Species Bos taurus
Tissues/Cell_line bovine retinal endothelial cells (BRECs)
Methods siRNA transfection, Western blot, qRT-PCR, semi-qPCR, ELISA
Expression pattern associated
Functional description Membrane translocation of H-Ras is a plausible mechanism responsible for accelerated apoptosis of retinal capillary cells in diabetes. H-Ras-siRNA prevented this translocation, and also decreased their apoptosis.
PubMed ID 19607814
Year 2009
Title Translocation of H-Ras and its implications in the development of diabetic retinopathy.
Drug-related ncRNA NO

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